There is seldom any need to (re)use a 'quicksave' unless you are going to repeat the same action in the exact same circumstances repeatedly (such as repeatedly 'bargaining' for a better price). You are given the ability to save 1000 game files for a reason and you can stretch that number out by deleting older saves.
Please see the 'Fourth Rule: Reloading 'save game' files' entry in the 'First Timer Advice' section of the wiki ' FNV General Mod Use Advice' article for the details. They do not include everything a 'full save' does and will eventually fail you. Do NOT rely upon 'quicksaves' as your 'save game' files.